As we all know by now, the mRNA in the Covid vaccine reprograms the DNA of some of the cells in the recipient’s body causing them to produce SARS-CoV-2 spike proteins which then circulate throughout the body. The purported idea was to stimulate the production of antibodies thus making the recipient “immune” – at least to severe illness. However, these proteins seem to possibly be amyloidogenic – which means that they can stimulate the production of amyloids. Let’s look at why this could be a serious problem.
What are amyloids and what are prions?
Amyloids are aggregates of proteins characterised by a fibrillar morphology and have been linked to the development of various diseases…Pathogenic amyloids form when previously healthy proteins lose their normal structure and physiological functions (misfolding) and form fibrous deposits within and around cells. These protein misfolding and deposition processes disrupt the healthy function of tissues and organs (Wikipedia).
These amyloids are, however, non-infectious in nature – meaning that they don’t “replicate” the mis-folding, rather, they form deposits called plaques, which, in itself, is dangerous enough. But there is a worse form of mis-folded protein that is infectious. These are called prions.
Prions are an infectious form of amyloids that can act as a template to convert other non-infectious forms. A prion /ˈpriːɒn/ ⓘ is a misfolded protein that can induce misfolding of normal variants of the same protein and trigger cellular death. Prions cause prion diseases known as transmissible spongiform encephalopathies (TSEs) that are transmissible, fatal neurodegenerative diseases in humans and animals. The proteins may misfold sporadically, due to genetic mutations, or by exposure to an already misfolded protein. The consequent abnormal three-dimensional structure confers on them the ability to cause misfolding of other proteins (Wikipedia)
The following articles and videos look at the very concerning question of whether the circulating spike protein is causing the formation of amyloids and/or prions and why that might be a problem.
Some Evidence
Amyloidogenesis of SARS-CoV-2 Spike Protein
SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein)
https://pubs.acs.org/doi/10.1021/jacs.2c03925
Amyloidogenesis: What Do We Know So Far?
The study of protein aggregation, and amyloidosis in particular, has gained considerable interest in recent times. Several neurodegenerative diseases, such as Alzheimer’s (AD) and Parkinson’s (PD) show a characteristic buildup of proteinaceous aggregates in several organs, especially the brain…At a time when the COVID-19 pandemic has hit the globe hard, the review also discusses the plausibility of the far-reaching consequences posed by the virus, such as triggering early onset of amyloidosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695042
When amyloids become prions
The conformational diseases, linked to protein aggregation into amyloid conformations, range from non-infectious neurodegenerative disorders, such as Alzheimer’s disease (AD), to highly infectious ones, such as human transmissible spongiform encephalopathies (TSEs). They are commonly known as prion diseases. However, since all amyloids could be considered prions (from those involved in cell-to-cell transmission to those responsible for real neuronal invasion), it is necessary to find an underlying cause of the different capacity to infect that each of the proteins prone to form amyloids has.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601197
More Evidence
The Conclusion
It is unclear at this time whether the circulating spike protein is indeed causing concerning changes in the way that our bodies fold proteins, but it is a question that needs to be asked . There have already been so many missteps and so much blatant negligence around the issue of spike protein and its effects on the human body and there is no question that good and transparent research needs to be done and made available to the general public so that each person can make informed choices about what to do next. Hopefully this information serves to promote a reasonable inquiry into the questions that have been ever-growing around the topic of safety and the reasonable path forward.